Persistent Protection from ticks and fleas.

*Studies show Simparica starts killing ticks in 8 hours and is ≥96.9% effective for 35 days against weekly reinfestations of Ixodes scapularis, Amblyomma americanum, Amblyomma maculatum, Dermacentor variabilis, and Rhipicephalus sanguineus.^1,2

IMPORTANT SAFETY INFORMATION
Simparica is for use only in dogs 6 months of age and older. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.

References:
<sup>1. Six RH, Geurden T, Carter L, et al. Evaluation of the speed of kill of sarolaner (Simparica) against induced infestations of three species of ticks (Amblyomma maculatum, Ixodes scapularis, Ixodes ricinus) on dogs. Vet Parasitol. 2016;222:37-42. doi:10.1016/j.vetpar.2016.02.014.
2. Six RH, Everett WR, Young DR, et al. Efficacy of a novel oral formulation of sarolaner (Simparica) against five common tick species infesting dogs in the United States. Vet Parasitol. 2016;222:28-32.</sup>

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