Across 6 studies, ProHeart 12 was administered to a wide variety of dogs 12 months of age and older*
- ProHeart 12 administered at 1x, 3x, and 5x the recommended dose did not result in any systemic adverse effects
- ProHeart 12 was used with 252 unique concurrent medications in the field study (eg, NSAIDs, antiparasitic agents, and antimicrobials)1
Studies support safety in:
- Female reproducing dogs and their offspring
- Male reproducing dogs
- Ivermectin-sensitive collies
- Heartworm-positive dogs*
Around the World, Zoetis Has Sold:
>12 million doses
of ProHeart 12†‡2
>20 million doses
of ProHeart 6†3
Adverse events associated with ProHeart 12 and ProHeart 6 were rare§2,3
The most common adverse events were vomiting, diarrhea, and lethargy. Less commonly mild injection site reactions (warmth, swelling) have been noted in some dogs.1
- In a field study, ProHeart 12 had a similar adverse events profile to Heartgard® Plus
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IMPORTANT SAFETY INFORMATION: Use PROHEART 6 in dogs 6 months of age or older and PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. Reported side effects in clinical trials included vomiting, lethargy, diarrhea, anorexia, and hypersensitivity reactions. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer these products. See full Prescribing Information for PROHEART 6 and PROHEART 12, attached.
References: 1. Study A161C-US-13-330. Data on File. Zoetis Inc. 2. ProHeart 12 Pharmacovigilance Data. Data on file. Zoetis Inc. 3. ProHeart 6 Pharmacovigilance Data. Data on file. Zoetis Inc. 4. Volume 6C: Summary of the Product Characteristics: SPC - Pharmaceuticals 2006. Data on file. Zoetis inc.
Heartgard Plus is a registered trademark of Boehringer Ingelheim.
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