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Any Dog Could Be
Infected, Anywhere

Clinical Signs Versus External Signs

Damage happens before standard heartworm antigen tests turn positive.¹

Heartworm-positive heart — The heart of a heartworm-positive dog is dissected to the level of the pulmonary valve.

A normal pulmonary artery like this can suffer damage from one or two heartworms long before diagnosis.

Significant pulmonary damage can occur in as little as 5 months.¹

Heart showing vascular damage — The heart of a heartworm-positive dog is dissected to the level of the pulmonary valve.

A normal pulmonary artery like this can suffer damage from one or two heartworms long before diagnosis.

Significant pulmonary damage can occur in as little as 5 months.¹

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Heartworm Disease Has Been Diagnosed in All 50 States²

>21% Increase in the average number of cases of canine heartworm disease*⁴

Average number of cases per reporting clinic:

<1 cases/clinic
1-5 cases/clinic
6-25 cases/clinic

26-50 cases/clinic
51-99 cases/clinic
>100 cases/clinic

Prevention Is Less Expensive Than Treatment

Treatment isn’t just expensive

It involves multiple injections of arsenic-based melarsomine dihydrochloride next to the spine, and often requires hospitalization⁵
Heartworm disease leaves the dog with serious and permanent damage to invaded organs even after the worms are gone¹
The process of treatment is a miserable experience for dogs, pet owners, and veterinarians

Illustration of balancing scales showing heartworm prevention vs heartworm treatment

*Per veterinary clinic 2013-2016.
^†Average cost for a 40-lb dog.

Stock photo of Opera House in Sydney, Australia

#1Prescribed Heartworm Preventative in Australia

Since 2000, doctors have administered ProHeart 12^‡ in Australia, the second-largest canine heartworm market in the world.

^‡Known in Australia as ProHeart SR-12.

IMPORTANT SAFETY INFORMATION: Use PROHEART 12 in dogs 12 months of age or older. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Hypersensitivity reactions may occur in some dogs when PROHEART 12 is administered alone or with vaccines. Anaphylactic and anaphylactoid reactions can result in death and should be treated immediately with the same measures used to treat hypersensitivity reactions to vaccines and other injectable products. The most common reported side effects in clinical trials were vomiting, lethargy, diarrhea, and anorexia. People should avoid inhalation, contact with eyes, or accidental self-injection. Certification is required before veterinarians and staff administer PROHEART 12. See full Prescribing Information.

Reference: 1. Jones, S. Heartworm disease: What lies beneath; DVM 360, April 19, 2018. 2. AHS Canine Guidelines 2018. https://d3ft8sckhnqim2.cloudfront.net/images/pdf/2018-AHS-Canine-Guidelines-181114.pdf?1542248135. 3. Heartworm Incidence Maps. https://www.heartwormsociety.org/veterinary-resources/incidence-maps. Accessed March 8, 2019. 4. Drake, Jason and Scott Wiseman. Increasing incidence of Dirofilaria immitis in dogs in USA with focus on the southeast region 2013 – 2016. Parasites & Vectors (2018) 11:39. 5. Rehm C. Do your heartworm protocols need an update? DVM 360. http://veterinarymedicine.dvm360.com/do-your-heartworm-protocols-need-update. Posted February 11, 2019. Accessed March 7, 2019. 6. The costs of heartworm treatment. American Heartworm Society. https://d3ft8sckhnqim2.cloudfront.net/images/infographics/0010-weigh-the-costs.jpg. Accessed January 23, 2019.

The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.

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This site is intended for U.S. Animal Healthcare Professionals. The product information provided in this site is intended only for residents of the United States. The products discussed herein may not have marketing authorization or may have different product labeling in different countries. The animal health information contained herein is provided for educational purposes only and is not intended to replace discussions with an animal healthcare professional. All decisions regarding the care of a veterinary patient must be made with an animal healthcare professional, considering the unique characteristics of the patient.