Frequently Asked Questions

Veterinarians must be ProHeart certified before they can purchase or administer ProHeart products. Only ProHeart-certified veterinarians can administer ProHeart products. Technicians and assistants can administer ProHeart products under the direction of a ProHeart-certified veterinarian. Veterinarians and veterinary staff can take the free certification course at any time.

If you are already certified to administer ProHeart 6, you do not need to recertify for ProHeart 12. However, you and your staff may want to retrain to learn about label updates.

In 3 studies, PROHEART 12 was 100% effective against heartworm disease* for one year. Learn more about efficacy.

*Caused by Dirofilaria immitis.

In 2 clinical effectiveness studies ProHeart 6 demonstrated 100% efficacy.

ProHeart 12 delivers a full year of heartworm disease prevention with just 1 veterinary-administered injection. ProHeart 6 offers continuous protection against heartworm disease with 2 injections per year.

The unique ProHeart MOA is constantly working to prevent heartworm disease in dogs, and works continuously vs short-term monthly chewables. Slow-dissolving microspheres contain and prolong the effects of moxidectin–which redistributes from plasma to adipose tissue. The adipose tissue acts as a reservoir, allowing efficacy. See ProHeart MOA.

Our Practice Resources provide a wide variety of print and social media resources and tools for you, your staff, and pet owners to help ensure practice success.

ProHeart 12 is indicated for use in dogs 12 months of age and older and ProHeart 6 is indicated for use in dogs 6 months of age and older. There are no upper age restrictions in healthy dogs.

Please see Prescribing Information for ProHeart 12 and Prescribing Information for ProHeart 6.

ProHeart 12 has been evaluated and found safe in female reproducing dogs and their offspring, male reproducing dogs, ivermectin-sensitive Collies, or Heartworm-positve dogs and dogs ≥ 12 months of age. Learn more.

ProHeart 6 has been evaluated and found safe in pregnant and lactating females and breeding males, ivermectin-sensitive Collies, and puppies ≥ 6 months of age. Learn more.

• Heartworm disease
• Hookworms, roundworms, and whipworms

Zoetis will work with you to ensure that you and your clients are satisfied with the performance of ProHeart or we will refund you the purchase price.*

The ProHeart Satisfaction Guarantee is available to individuals who have purchased ProHeart from, and have had ProHeart administered by, a ProHeart-certified licensed veterinarian, technician, or staff member. All claims are evaluated on a case-by-case basis based on the program guidelines and requirements outlined here.

1. Heartworm Disease Guidelines: If any dog determined by a licensed veterinarian to be free of heartworm infection at the onset of treatment with ProHeart develops heartworm disease, we will provide reimbursement (up to $1000 and the acquisition cost of melarsomine dihydrochloride) associated with the diagnosis and treatment of heartworm disease and provide a year’s supply of ProHeart.
2. Hookworms, roundworms and whipworms: ProHeart treats adult and larval hookworm infections existing at the time of administration. ProHeart does not have label indications to treat roundworm and whipworm infections. However, if you are administering ProHeart and a dog tests positive for any of these parasites, Zoetis will pay the reasonable and customary costs up to $100 for an approved treatment. The veterinarian may determine the appropriate treatment.

*Subject to program requirements as outlined in this document.